РЕВМАТОИДНЫЙ АРТРИТ У ЛИЦ СТАРШЕ 60 ЛЕТ

Аннотация

It was examined clinical features, data of joint syndrome, neurotic changes and the level of hormones in blood in 48 patients with rheumatoid arthritis (RA) (women - 32, men - 16) in the age from 60 to 73 years old (in average 69,5±2,2 years) and 40 patients (women - 31, men - 9) in the age from 16 to 59 years old. In patients older 60 years it was often determined the high level of the activity of the disease (according to DAS 28), significant deterioration of roentgenological signs and functional condition of the patients. For this disease it was typical more severe beginning, injures of the big joints such as knee joint, humeral and the ankle and the development of the significant component of exudation due to the asymmetric oligoarthritis. Most accompanying diseases were arterial hypertension (45,8%), ischemic heart disease (41,6%). The carried out research was promoted to reveal the neurotic disorders in 72,7% of patients: in 22,7% - weak, in 35,2% - moderate and in 14,8 % - high degrees of disorders. In group of the patients in the age of till 60 years old neurotic symptoms were revealed in 60,0 % of patients, and in group of the patients older than 60 years - in 83,3% of patients such symptoms were revealed in 1,4 times more often. In group of the patients older 60 years old the level thyrotrophin-releasing hormone (TRH), triiodothyronine, adrenocorticotrophic hormone (ACTH) and cortisol were authentic lower than in patients till 60 years old (P < 0,05 and P < 0,02), and the level thyroxine not always correlated with age and did not correspond to the level of TRH and triiodothyronine.