Влияние внутриутробного и раннего постнатального воздействия пестицидов на рост и становление вилочковой железы потомства

Аннотация

The aim of the study was to identify the toxic effect of intrauterine and early postnatal exposure to pesticides on the development of the thymus gland of offspring. The experiments were performed on white adult male rats, who respectively received pesticides cyhalothrin or fipronil during pregnancy and lactation. Progeny from experimental and control animals was studied on the 3rd, 7th, 14th, 21st and 30th days after birth using methods of morphology, electron microscopy and immunohistochemistry. It was shown that the toxic effect of pesticide exposure during pregnancy and lactation is manifested in the form of slowing growth and formation of the thymus of offspring. Along with the increase in death of thymocytes within the body, the action of pesticides leads to a decrease in the secretory activity of epithelio-reticular cells Tm, indicating violations of the regulatory function of the thymus. In the mechanism of toxic effect of pesticides on the immune system, the imbalance between proliferation and apoptosis of cells is caused by both direct toxic effects of drugs, both developing hypothyroidism and oxidative stress in mother and offspring. This causes the need for early detection of hypothyroidism and oxidative stress in pregnant women and newborns, followed by their pharmacological correction.