Постнатальное становление периферических органов иммунной системы потомства в условиях воздействия пестицидов через организм матери

Аннотация

The purpose of the work is to reveal the structural and functional features of postnatal growth and the formation of peripheral organs of the immune system of offspring obtained under the influence of pesticides through the mother's organism. The experiments were performed on white adult female rats, who respectively received pesticides lambda-cyhalothrin or fipronil during pregnancy and lactation. Progeny from experimental and control animals was studied on the 3rd, 7th, 14th, 21st and 30th days after birth using methods of mor-phology, electron microscopy, mmunohistochemistry and biochemistry. It has been shown that the toxic effect of pesticide exposure during pregnancy and lactation is manifested in the form of growth retardation and for-mation of the peripheral immune organs – lymph nodes and spleen. In the mechanism of toxic effect of pesti-cides on the peripheral immune system the leading role is played by the imbalance between proliferation and apoptosis of cells, caused both by direct toxic effects of drugs, both developing hypothyroidism and oxidative stress in mother and offspring. This causes the need for early detection of hypothyroidism and oxidative stress in pregnant women and newborns, followed by their pharmacological correction