Роль печени в холецистокининовых механизмах регуляции поджелудочной железы

Аннотация

Studies were performed on 98 rats in 14 series, 7 acute experiments in each series. We studied the change in pancreatic secretion with the introduction of CCK.-8 short-chain peptide and CCC-33 long-chain peptide in the presence of trypsin and contrical. It was concluded that the short-chain peptide CCK.-8 is utilized by the liver to a large extent, in comparison with the long-chain peptide CCK-33. Trypsin, when passing through the liver, reduces the ability of the liver to utilize CCK.-8, thereby stimulating the secretory function of the pancreas. When passing through the liver, the protease inhibitor increases the ability of the liver to utilize CCK.-8, thereby reducing the secretory function of the pancreas. Pancreatic hormone trypsin and its inhibitors may be involved in the modification of cholecystokinin mechanisms for regulating pancreatic function.