DIFFERENTIAL LACTATE DEHYDROGENASE ACTIVITY ASSESSMENT IN CEREBROSPINAL FLUID ACROSS VARIOUS MENINGITIS ETIOLOGIES

Аннотация

This study investigates the utility of assessing lactate dehydrogenase (LDH) activity in cerebrospinal fluid (CSF) as a diagnostic and differentiating marker across diverse etiologies of meningitis. Meningitis, characterized by inflammation of the meninges, can have various underlying causes, including bacterial, viral, and fungal infections. We conducted a comprehensive analysis of LDH activity in CSF samples from individuals with different etiologies of meningitis. Our findings reveal significant variations in LDH activity levels between the etiological groups, suggesting the potential of LDH as a discriminatory tool for distinguishing between bacterial, viral, and fungal meningitis cases. This research contributes to improving meningitis diagnosis and guiding timely treatment decisions. KEYWORDS Lactate dehydrogenase, cerebrospinal fluid, meningitis etiology, diagnostic marker, bacterial meningitis, viral meningitis, fungal meningitis, inflammatory response, differential diagnosis, treatment decisions.