This article presents an overview of the main medications and natural remedies used in hepatobiliary system pathology

Аннотация

This article presents an overview of the main medications and natural remedies used in hepatobiliary system pathology. Classification of hepatoprotectors by mechanisms of their action is reflected, and indications for the use of the main groups of these drugs. Special attention paid to a large group of plant hepatoprotective agents, the mechanism of their action in accordance with their chemical composition. In accordance with their chemical composition. Tables of medicinal plants, dietary supplements, on hepatoprotective and choleretic action, because of clinical and experimental studies. Key words: hepatoprotectors, flavonoids, phospholipids, lipid peroxidation, lipids, liver Introduction. Hepatoprotectors are drugs or combinations of drugs that used to increase the liver's resistance to damaging factors, prevent or reduce disruption of the organ's structure and function. Modern principles of treatment of liver diseases include two main directions. The first is to eliminate the cause of the disease, such as antiviral therapy for viral hepatitis. The second is to slow down the destruction of the organ, restore the structure and work of cells. For this purpose, hepatoprotectors are used. Despite the fact that the causes of hepatic pathology are diverse, doctors’ claim that most chronic liver diseases progress by the same mechanisms. It all starts with the stage of damage; with impaired bile outflow through intrahepatic and extrahepatic bile ducts, then inflammation, fibrosis, cirrhosis and hepatic cell failure occur. That is why hepatoprotectors indicated in different liver diseases and should act on all these mechanisms, especially on fibrosis, as the stage of the disease depends on its severity. Most often-liver damage realized through chemical and immunological mechanisms. In recent decades, diffuse liver diseases of predominantly viral etiology have taken a strong position among the most common liver diseases. Predominantly viral etiology have taken a strong position among the most urgent problems of modern medicine. Urgent problems of modern medicine, 5 ACADEMIC RESEARCH IN MODERN SCIENCE International scientific-online conference because they reduce the quality of patients, lead to disability. In recent years, the knowledge in the field of etiology, immunogenesis knowledge in the field of etiology, immunogenesis, and pathmorphology of these diseases considerably expanded in recent years. Possibilities of diagnostics and specific prophylaxis. The most difficult and far issue of therapy of patients with acute and chronic viral hepatitis (VH) remains the most difficult and far from being solved. Hepatitis (VH), steatohepatitis of alcoholic and non-alcoholic etiology. In accordance with modern principles of treatment of liver diseases, the program of complex therapy of such pathology includes two main directions. The first represents etiotropic therapy aimed at suppressing the pathologic pathogen, its elimination and sanitation of the body. In clinical practice etiotropic therapy used only in viral hepatitis with parenteral mechanism of infection. The second direction corresponds to pathogenic therapy, aimed at adequate pharmacological correction of universal, multifactorial and multitemporal links of pathogenesis. It should be noted that universalism of the main links of pathogenesis of various liver lesions and allows to polyetiologic character of this pathology to use rather close pathogenetic therapy. Pathogenetic therapy, the basis of which may be drugs with a targeted action on hepatic cells when discussing the pathogenetic therapy of HBV, it is necessary to consider the general provisions and some features in acute and chronic infections. Some peculiarities in acute and chronic infections. In acute HBV, signs of liver dysfunction detected in the midst of the disease, and their severity correlates with the severity of the course of the disease. Liver and the degree of their severity correlates with the severity of the course of the disease. Despite the presence of diffuse liver damage, cytolysis and dystrophy of hepatocytes in the majority of cases, the disease is mild. The majority of cases of diseases occur in mild and moderately severe forms, that due to the enormous compensatory-adaptive capabilities of this both this organ, as well as systems and the whole organism. For example, HAV is an acute, self-limiting disease, characterized by a benign course, and in the majority of cases represented by mild low-symptoms. Most cases represented by mild, asymptomatic forms. Mild forms VH essentially do not need drug therapy. The main task of therapeutic measures is to create optimal conditions for sanogenesis and repairing. This achieved by limiting various loads on the liver as an organ involved in metabolism detoxification, digestion and regulation of metabolic processes. A similar hepatoprotective effect observed when administering selenium containing compounds, thiobarbituric acid derivatives In thei