Методы коррекции минимальных мозговых дисфункций у детей раннего возраста

Аннотация

Bir yoshgacha bulgan 90 nafar bolalarning klinika-biokimyoviy kursatgichlari tekshirilgan: asosiy guruhni MAT ning perinatal shikastlanishining asoratlarini tiklash uchun davolanayotgan 44 nafar bola tashkil etdi, nazorat guruhini PEP bilan kasallangan 26 nafar tashkil qilib, bundan tashqari 20 nafar sog’lom bolalarda LPO holati o’rganib chiqildi. Izlanish natijalari shuni ko‘rsatdiki bemor bolalarda LPO jarayonining kamayishi yoki ayrim paytlarda, ularning nomutanosibligi aniklandi. Oksibral qo‘llanishi LPO ko‘rsatkichlarining tiklanishi bilan birgalikda nevrologik belgilarining tezroq ijobiy o‘zgarishlariga, ya'ni, bolalarning tinchlanishi, uyqusining yaxshilanishiga olib keldi. Oksibralni qo‘llash vaqtida miya qobig‘i bosimi tezroq normallashdi. Nevrologik buzilishlarida oksibralni qo‘llash reabilitasiyani tezlashtiradi va bolalarda MATning perinatal jarohatlari qoldiqlari foizini ancha kamayishiga olib keladi. Kalit so'zlar: asab tizimining perinatal shikastlanishining oqibatlari, chaqaloqlar, lipid peroksidlanishi, davolash Sharipov Rustam Haitovich, Doctor of Medical Sciences, Associate Professor, Department of Pediatrics and General Practice Faculty of Postgraduate Education Rasulova Nodira Alisherovna, Assistant at the Department of Pediatrics and General Practice Ahmedova Mahbuba Mahmudovna, Associate Professor at the Department of Pediatrics and General Practice Rasulov Alisher Sobirovich, Associate Professor at the Department of Pediatrics and General Practice Irbutaeva Lola Tashbekovna, Associate Professor at the Department of Pediatrics and General Practice Samarkand State Medical Institute Samarkand, Uzbekistan METHODS FOR CORRECTING MINIMUM CEREBRAL DYSFUNCTIONS IN YOUNG CHILDREN ANNOTATION By the purpose of work was the substantiation of therapy with oxibral of milk-feted children with prenatal damages of the central nervous system (CNS) by the account of changes of processes lipid peroxidation LP. In work 137 JOURNAL OF HEPATO-GASTROENTEROLOGY RESEARCH | ЖУРНАЛ ГЕПАТО-ГАСТРОЭНТЕРОЛОГИЧЕСКИХ ИССЛЕДОВАНИЙ №3,2 (том II) 2021 analyzed the results of biochemical researches at 90 children of the first year of life: the basic group was made with 44 children with prenatal damages of CNS, control group - 26 children with consequences of perinatal damage to the nervous system, also have studied a status of processes a LP at 20 healthy children. The results of researches have shown, that at children with prenatal damages CNS reveal significant infringements in processes a LP, which is possible were characterized as decreasing and in some cases their misbalance. The assignment of oxibral to children with prenatal damages of CNS alongside with normalization of parameters a LP to faster improvement of neurological symptoms: children become quiet, active, the dream normalizing. Intra skull pressure on a background of prescription Oxibral was reduced much faster. The opportunity of correction neurological infringements with oxibral opens prospect of rehabilitation and promotes significant to reduction of percent of children with the residual phenomena of prenatal damages CNS. Key words: consequences of perinatal damage to the nervous system, infants, lipid peroxidation, treatment. Dolzarbligi. Perinatal miya shikastlanishi onalardan tug'ilgan. Nevrologik holatida bolalarning bolalikdagi asab tizimining barcha patologiyalarining 42,8% gipertenziv-gidrosefalik sindromi, vegetativ- 60% dan ko'prog'ini tashkil qiladi, miya falaji, epilepsiya visseral disfunktsiyalari - 38,5% da, neyro -refleks va minimal miya disfunktsiyasi kabi kasalliklarning qo'zg'aluvchanligining oshishi - 11,4% da, psixomotor rivojlanishida bevosita ishtirok etadi. Hozirgi vaqtda PEP rivojlanish kechikish sindromi - 7,1% da aniqlandi. patogenezining asosiy gipotezasi serebrovaskulyar bo'lib, Bo’limda nazorat guruhi bolalariga kompleks terapiya uning diqqat markazida miya qon oqimining miya qilindi: miya qon aylanishini yaxshilovchi (vinpotsetin), metabolizmi bilan "bog'lanishi" mavjudligining haqiqiy piratsetam preparatlar qo'llanildi, sindromli terapiya haqiqati hisoblanadi. Ma'lumki, gipoksiya sharoitida o'tkazildi. Asosiy kasalliklardan kelib chiqqan lipidlarning periks oksidlanishi (LPO) neyron buzilishlarni tuzatish ham amalga oshirildi. membranalariga halokatli ta'sir ko'rsatadigan agressiv Tadqiqot natijalari va ularning muhokamasi. erkin radikallar, gidroperoksidlar to'planishi bilan Tadqiqot natijalari shuni ko'rsatdiki, perinatal markaziy bezovtalanadi. Perinatal markaziy asab tizimining asab tizimi shikastlangan bolalarda LPO jarayonlarida shikastlanishlarida mikrosirkulyatsiya buzilishi va sezilarli buzilishlar aniqlangan, ular pasayish va ayrim metabolik kasalliklarni tuzatish uchun bir qator dori- hollarda ularning nomutanosibligi bilan tavsiflangan. Bu darmonlar qo'llaniladi, ularning ta'siri hujayralarning inkubatsiyadan oldin va keyin MDA tarkibining sezilarli funktsional holatini normallashtirishga qaratilgan. darajada o