Комплексное лечение бронхиальной астмы у детей, с применением препарата резистол

Аннотация

Обследованы 78 детей с разной степенью тяжести бронхиальной астмы в поликлинике стационара, отделениях поликлиники и неотложной терапии Андижанского государственного медицинского института в возрасте 6-14 лет. Для проспективного исследования мы сформировали две группы пациентов: первая группа - пациенты, получавшие стандартную базовую терапию и плацебо (n = 35); вторая группа пациентов (n = 43), получавших наряду с базовой терапией препарат «Резистол». Прием этого препарата подавляет метаболизм кортикоидных гормонов в организме и продолжительность их действия увеличивается. Собственные исследования показали, что в 1-й группе нам удалось снизить дозу ингаляционных глюкокортикостероидов на 13,5 ± 3,1%, что особенно ценно при нарушении чувствительности β2-адренорецепторов в результате чрезмерного употребления сальбутамола. Положительным эффектом препарата было уменьшение количества дневных и ночных приступов, увеличение абсолютных значений ПСВ и уменьшение выраженной вариабельности. Значения ICC нормализовались более эффективно у большинства пациентов. Таким образом, лечение препаратом «Резистол» не только способствовало более эффективной реабилитации детей с бронхиальной астмой, но и повышению параметров функции внешнего дыхания. Кроме того, благоприятно 130 JOURNAL OF HEPATO-GASTROENTEROLOGY RESEARCH | ЖУРНАЛ ГЕПАТО-ГАСТРОЭНТЕРОЛОГИЧЕСКИХ ИССЛЕДОВАНИЙ №3,2 (том II) 2021 сказалось на состоянии верхних дыхательных путей, способствуя, по всей видимости, уменьшению выраженности аллергического воспаления. Ключевые слова: бронхиальная астма у детей, иммунология, резистол. Introduction. The problem of asthma continues children. to be relevant throughout the world, despite numerous Materials and methods: Under our supervision studies and a sufficient amount of treatment and in the clinic of the department of hospital, polyclinic and preventive measures. In childhood, bronchial asthma is emergency treatment of the Andijan State Medical one of the most common chronic diseases [1,2,3,8]. Institute based on ODMMTS Andijan there were 78 According to the results of a number of children with varying degrees of severity of bronchial researchers, the prevalence of asthma in the Republic of asthma between the ages of 6-14 years. For a prospective Uzbekistan varies from 3.1% to 8.2%, which is due not study, we formed two groups of patients: the first group only to the influence of external regional factors, but also of patients who received standard basic therapy (n = 35); to the use of various diagnostic methods [1]. However, as the second group of patients (n = 43) who received, along shown by virtually all studies conducted under the with a similar range of basic therapy, received the drug ISAAC (Intemacional Study of Astma and Allergy in Resistol on a five-day schedule (1-day 1.0 ml, 2-day 1.5 Children) program in all regions of the planet, the true ml, 3-day 2.0 ml, 4-day 2.5 ml, 5-day 3.0 ml. incidence of asthma was significantly higher than official Intramuscularly) with a break of 1 day, 3 times. The statistics [7,8,9]. The discrepancies between official duration of "Resistol" therapy was 15 days. The duration statistics on recruitment and the results of of the observation of the patients of the studied groups epidemiological studies are also associated with the lasted for a year. In addition to age, the criteria for underdiagnosis of bronchial asthma in different age inclusion in the study group were verification of the groups. diagnosis of bronchial asthma, mild, moderate, severe Analysis of epidemiological studies in the city disease. The exclusion criteria from the study group were of Andijan showed that in the structure of the prevalence severe for the disease using systemic glucocorticoids for of allergic diseases, bronchial asthma is in 2nd place (5.6 more than 6 months. + 0.03%), yielding to allergic rhinitis (12.7 + 0.19%) [1]. All observed patients received hydrocortisone as Despite the use of increasingly effective means a basic therapy in the form of a metered-dose inhaler. for anti-inflammatory therapy of respiratory allergies, up Depending on the severity of asthma, the daily dose of to a third of patients continue to complain about the the drug averaged 25-50 mg. All observed patients were persistence of symptoms of the disease even when it is given a short-acting β2-adrenomimetic - (salbutamol). In carried out in an adequate age dosage. all cases, undesirable drug reactions were recorded. Unfortunately, treatment with inhaled Against the background of the use of the drug "Resistol" corticosteroids, being the most effective one currently we have not registered the side effects of the drug. used, has a number of side effects, including depression The survey included monitoring peak expiratory of the hypothalamus-pituitary-adrenal cortex axis, the flow rate over the entire observation period, assessing the formation of local candidiasis, and others [4.9]. In this quality of life using a specially designed