Особенности проявления пищевой аллергии у детей с атопическим дерматитом

Аннотация

Tadqiqotning maqsadi atopik dermatit (AD) bo'lgan bolalarda oziq-ovqat allergiyasining (FA) klinik va immunologik individualligini aniqlash edi. Tekshiruvga turli xil orttirilgan patologiyaning o'jar kursidan aziyat chekadigan 2 yoshdan 14 yoshgacha bo'lgan 88 bola (16% maktabgacha yoshdagi bolalar va 84% 8 yoshdan oshgan bolalar) kiritilgan. Immunologik tekshiruv maxsus Allergopharma test tizimlari yordamida o'tkazilgan oziq-ovqat allergenlariga (sigir suti oqsili, a-laktoalbumin, b-laktoglobulin, kazein, soya oqsili, echki suti oqsili) qon zardobida allergenga xos IgE va IgG antikorlarini aniqlashni o'z ichiga oladi. . Biz 1,5 oylikdan 3 yoshgacha bo'lgan (o'rtacha yoshi 14, 05 ± 1, 3 oy) AD bo'lgan 95 nafar bolani (52 o'g'il, 43 qiz) kuzatdik. 1,5 oydan 12 oygacha 55 (57,9%) bolalar, 1 yoshdan 3 yoshgacha mos ravishda 40 (42,1%) bolalar. Kasallik birinchi marta 78 (82,5%) 6 oygacha bo'lgan bolalarda, 17 yoshda namoyon bo'ldi. Kasal bolalarning umumiy sonidan 48 tasi (50, 9%) noqulay kursga ega (SCORAD indeksi 58, 14 ± 2, 63 ball); 32 (33, 3%) bola o'rtacha kursga ega (SCORAD indeksi - 32, 03 ± 1, 43 ball), 15 (15, 8%) bolalar og'ir kursga ega (SCORAD indeksi -12, 12 ± 1, 43). ball). Olingan natijalar asosida AD immunopatogenezi asosan yallig'lanishga qarshi interleykinlar: IL-4, IL-5 ta'siri bilan tavsiflanadi va Th2- hujayralarning kuchayishi bilan bog'liqligini tasavvur qilish mumkin. Shunday qilib, IgE va Ig G ni yanada keng tarqalgan PA ga aniqlash bilan yosh bolalarning allergologik tekshiruvi AD klinik ko'rinishlarining xususiyatlarini aniqlaydigan immunitet reaktsiyasining o'ziga xos xususiyatlarini aniqlashga imkon beradi. Kalit so'zlar: atopik dermatit, oziq-ovqat allergiyasi, namoyon bo'lish xususiyatlari, allergik reaktsiyalar turlari Ganiev Abdurashid Ganievich, is an associate professor of the Department of Hospital Pediatrics at the Andijan State Medical Institute. Andijan, Uzbekistan Temirova Oydin Husan qizi, is a third-year Master of the Department of Hospital Pediatrics of the Andijan State Medical Institute. Andijan, Uzbekistan Abdullayeva Shahnoza Nurulla qizi, is a second-year master of the Department of Hospital Pediatrics of the Andijan State Medical Institute. Andijan, Uzbekistan 100 JOURNAL OF HEPATO-GASTROENTEROLOGY RESEARCH | ЖУРНАЛ ГЕПАТО-ГАСТРОЭНТЕРОЛОГИЧЕСКИХ ИССЛЕДОВАНИЙ №3,2 (том II) 2021 PECULIARITIES OF THE MANIFESTATION OF FOOD ALLERGIES ALLERGIES IN CHILDREN WITH ATOPIC DERMATITIS ANNOTATION The aim of the study was to determine the clinical and immunological individualities of food allergy (FA) in children with atopic dermatitis (AD). Eighty-eight children with AD between 2 and 14 years of age (16% were preschool children and 84% were children older than 8 years) suffering from a stubborn course of different acquired pathology were included in the examination. Immunological examination included determination of values of allergen- specific IgE and IgG antibodies in blood serum to food allergens (cow's milk protein, α-lactoalbumin, β-lactoglobulin, casein, soy protein, goat milk protein) conducted with support of special Allergopharma test systems. We monitored 95 children with AD (52 boys, 43 girls) aged from 1, 5 months to 3 years (mean age 14, 05 ± 1, 3 months). From 1, 5 to 12 months there were 55 (57, 9%) children, from 1 to 3 years respectively 40 (42, 1%) children. The disease manifested for the first time in 78 (82, 5%) children under 6 months of age, in 17 (17, 5%) children after 6 months. Of the total number of ill children, 48 (50, 9%) had an uneasy course (SCORAD index was 58, 14 ± 2, 63 points); 32 (33, 3%) children had a moderate course (SCORAD index - 32, 03 ± 1, 43 points), and 15 (15, 8%) children had an unsevere course (SCORAD index -12, 12 ± 1, 43 points). On the basis of the results obtained, it is possible to imagine that the immunopathogenesis of AD is characterized mostly by the impact of pro-inflammatory interleukins: IL-4, IL-5 and associated with increased vigor Th2-cells. Thus, allergological examination of young children with determination of IgE and Ig G to even more common PA allows us to detect the peculiarities of the immune response, which determine the features of the clinical manifestations of AD. Keywords: atopic dermatitis, food allergy, features of manifestation, types of allergic reactions Relevance. Atopic dermatitis is characterized by directly to an allergist about their typical manifestations an early onset, polymorphism of the clinical picture, of allergy (dermatitis, bronchial asthma). The majority complex pathogenesis and various causes of its (75%) were patients who were treated in the somatic occurrence [1,2.10]. A triggering factor for the departments for the underlying disease or were registered development of AD in most cases is a food Allergy (PA), by a pediatrician or narrowly specialized physicians which can not only exacerbate, but also to maintain a (neurologist, rheumatologist, otolaryngologist). All severe cours