Структурно-гемодинамические изменения головного мозга в неонатальном периоде у детей раннего возраста с внутриутробной гипоксией

Аннотация

The study was conducted in Samarkand City Maternity Hospital No. 1, among 40 babies born with intrauterine hypoxia on time and prematurely, by caesarean section and physiologically. The control group included 10 healthy, physiologically born babies. The study of the structural and hemodynamic properties of the infant brain in the study group is performed using standard methods of neurosanography with color mapping and pulse wave dopplerometry. Intra-group comparisons have shown that the incidence of ischemic-hemorrhagic disorders increases with gestational age in children. However, according to the analysis of cerebral electrophysiological activity in the neonatal period in the study group, taking into account the structural and hemodynamic changes detected in the brain in children with intrauterine hypoxia, the electrophysiological activity of the brain in children born during natural sleep at 7 days, preterm infants should be evaluated based on the results of electroencephalography (EEG) performed at 36-38 weeks of gestation. Summarizing the results, we can conclude that in children with intrauterine hypoxia, in contrast to healthy children, significant structural and hemodynamic disorders of the brain are associated with cesarean delivery. Keywords: Newborn, hypoxia, neurosanography, fetus, hypoperfusion Homiladorlik va tug'ish jarayonini negizida homila va yangi tug'ilgan chaqaloq uchun murakkablashtiradigan ko'plab shart -sharoitlarning universal bo'lgan zararli omil - bir nechta organlar 96 JOURNAL OF HEPATO-GASTROENTEROLOGY RESEARCH | ЖУРНАЛ ГЕПАТО-ГАСТРОЭНТЕРОЛОГИЧЕСКИХ ИССЛЕДОВАНИЙ №3,2 (том II) 2021 disfunktsiyasining rivojlanishiga olib keluvchi, asosiy guruhlarida o'tkazilgan Doppler tadqiqotlari natijalariga energiyaga bog'liq jarayonlarni buzuvchi, patologik ko'ra, qon tomir tonusini tavsiflovchi RI indeksining endogen reaksiyalar majmuasini qo'zg'atadigan gipoksiya o'rtacha qiymatlari yosh me'yorlariga to'g'ri keladi (RI = jarayoni yotadi [1, 4, 9, 10]. Rivojlanayotgan miya 0,70-0,73). Ammo, tug'ilish turidan qat'i nazar, bachadon gipoksiya ta'siriga eng ta'sirchandir, bunda boshlangan ichi gipoksiyaga uchragan bolalarda RI ning keng patologik biokimyoviy jarayonlar energiyaga bog'liq o'zgarishi aniqlandi. Shu bilan birga, ikkala taqqoslash bo'lgan neyrotransmitterlardan foydalanish guruhidagi bemorlarning yarmida RI 0,80 tez -tez o'sish tendentsiyasi nogironliklar, nutqni rivojlanishidagi kechikishlar, kuzatilgan (17,5% va 12,4%, p> 0,05) va erta tug'ilgan bolalarning ijtimoiy moslashuvchanligidagi cheklashlar chaqaloqlarning ayrimlarida RI> 0,80 o'sishi statistik yuzaga keladi [ 2, 6, 7, 11]. jihatdan I guruh bolalarida, analogik yoshdagi tabiiy yo’l Tadqiqot maqsadi. Gipoksiya kechirgan bilan tug’ilganlarga nisbatan ko'pligi aniqlandi - 22,3% chaqaloqlar neonatal davrida bosh miyaning struktur- va 12,7% (χ² = 4,09, p = 0,043). gemodinamik xususiyatlarini baholash. I guruhdagi bolalarda, diastolik tezlikning Tadqiqot materiali va usullari. Izlanish susayishi-8,7±0,33 sm/sek, taqqoslash guruhidagilarga Samarqand shaxar 1 son tug’ruqxonasida homila ichi nisbatan- 9,9±0,38 sm/sek kabi gemodinamik gipoksiyasi bilan muddatida va muddatidan oldin, o’zgarishlari yaqqol namoyon bo'lib (р=0,042), asosan kesarcha kesish va fiziologik yo’l bilan tug’ilgan 40 nafar 32-34 xaftaligida kesarcha kesish yo’li bilan tug’ilgan chaqaloqlar orasida olib borildi. Nazorat guruhiga 10 bolalarda -6,4±0,42 sm/sek, analogik yoshda tabiiy yo'l nafar sog’lom, muddatida fiziologik yo’l bilan tug’ilgan bilan tug'ilgan bolarga - 7,7±0,56 sm/sek nisbatan past chaqaloqlar kiritildi. Tadqiqot guruhidagi chaqaloqlar ko’rsatkichda kuzatildi (р=0,032). Bundan tashqari bu bosh miyasining struktur-gemodinamik xususiyatlarini bolalarda , tabiiy yo’l bilan tug’ilganlarga nisbatan bosh o’rganish standart metodlar asosida rangli kartirlash bilan miya gipoperfuziyasining yuqori chastotasi qayd etildi : neyrosanografiya o’tkazish va impuls to’lqinli V max 0,05)