Показатели дисбиоза и воспаления у крыс с пародонтитом на фоне гипер- и гипотиреоза

Аннотация

The issues of hormonal regulation of inflammatory reactions in periodontium and their development on the background of thyroid gland dysfunction remain insufficiently studied. The markers of inflammation and periodontal microbiocenosis in rats with periodontitis without concomitant pathology and on the background of hyper- and hypothyroidism have been studied. The results of our studies showed that the urease activity in the periodontal tissues homogenate of rats with periodontitis increased by 3.1 times, in rats with periodontitis and hyperthyroidism by 5.1 times, in rats with periodontitis and hypothyroidism by 3.8 times compared to the control group. At the same time, the changes in lysozyme activity in the homogenate of periodontal tissues were multidirectional. Thus, in rats with periodontitis on the background of hyperthyroidism this index significantly increased by 13.9%, in rats with periodontitis on the background of hypothyroidism - decreased by 1.9 times compared to the control group. The activity of elastase in the homogenate of periodontal tissues in rats with periodontitis increased by 50.8%, in rats with periodontitis and hyperthyroidism by 92.3%, in rats with perio-dontitis and hypothyroidism by 73.2% compared to the control group. It has been concluded that experimental periodontitis is accompanied with the increase in elastase and urease activities and the decrease in lysozyme activity in the homogenate of periodontal tissues. These data indicate on the development of local inflammatory reactions, a pronounced degree of dysbiosis, and the decrease in the level of nonspecific protection. Imbalance of thyroid hormones strongly affects the course of periodontitis, especially in hyperthyroidism