QUINAZOLINONE: PHARMACOPHORE WITH ENDLESS PHARMACOLOGICAL ACTIONS

Аннотация

Quinazolinone is a heterocyclic compound that exhibits a wide range of pharmacological activities. This review article aims to explore the various pharmacological actions of quinazolinone and the underlying mechanisms of action. Quinazolinone has been found to possess a broad spectrum of biological activities, including anti-cancer, anti-inflammatory, antimicrobial, anti-tubercular, anti-diabetic, and anti-hypertensive activities, among others. This review provides an in-depth analysis of the various pharmacological properties of quinazolinone, its chemical structure, and the mechanisms of action involved in these activities. The quinazolinone nucleus has been recognized as an important pharmacophore that is present in a variety of biologically active compounds. Due to its versatile nature, quinazolinone-based compounds have been studied for their diverse pharmacological activities, such as anti-inflammatory, anti-cancer, anti-diabetic, anti-microbial, and anti-viral effects. This review provides an overview of the various quinazolinone derivatives, their chemical structure, and the wide range of pharmacological actions that they exhibit. The underlying mechanisms of these pharmacological actions are also discussed in detail, highlighting the potential therapeutic applications of quinazolinone derivatives. Overall, this review underscores the importance of quinazolinone derivatives as an interesting scaffold for the design and development of novel pharmacologically active compounds.