Research Article

Аннотация

The article discusses the association between connective tissue dysplasia (CTD) and arrhythmias, particularly focusing on mitral valve prolapse as a potential risk factor for life-threatening ventricular arrhythmias and sudden cardiac death. Various studies emphasize the structural and mechanical abnormalities in the heart that contribute to arrhythmogenic phenotypes in CTD patients, such as fibrosis, mitral annular disjunction, and accessory chordae. Additionally, the text explores the role of autoantibodies, cardiac remodeling, and autoimmune processes in mediating rhythm disturbances and cardiac complications in CTD. The importance of ECG analysis, neural networks, and stress tests in detecting and monitoring arrhythmias in CTD patients is highlighted. The research underscores the significance of understanding the morphological basis and pathophysiological mechanisms of arrhythmias in CTD patients to improve therapeutic strategies and enhance patient outcomes. KEYWORDS Connective tissue (CT), Connective tissue dysplasia (CTD), Mechanoelectric feedback (MEFE), heart rhythm disorders, mitral annular disjunction (MDA), sudden cardiac death (SCD), Stretch-activated channels (SACs). Volume 04 Issue 06-2024 32 International Journal of Medical Sciences And Clinical Research (ISSN – 2771-2265) VOLUME 04 ISSUE 06 PAGES: 32-39 OCLC – 1121105677 Publisher: Oscar Publishing Services Servi