Патоморфология дилиатационной кардиомиопатии

Аннотация

The aim of the investigation was to study the pathomorphological changes in the structures of the myocardium in dilated cardiomyopathy (DCM). We obtained autopsy materials for DCM cases at the Republican Center for Pathological Anatomy over the past 20 years (2010 2020), and also analyzed the autopsy protocols and medical history. Sudden development of heart failure of the right and left ventricles with DCM, cardialgia and angina pectoris; In some cases, with thromboembolism, cardiac arrhythmias were observed, often accompanied by ventricular fibrillation, ventricular extrasystoles and blockade of conduction. Histologically, the following types of pathological changes were observed in the myocardium and endocardium with DCM: excessive proliferation of interstitial connective tissue, the development of myxamatosis, and sometimes lipomatosis. The main changes characteristic of DKMP were muscle fiber dilatation, that is, thinning of muscle fibers, thinning, fragmentation and homogenization of cardiomyocytcs, disordered arrangement of nuclei, and deformation and degeneration due to changes in the environment.