В статье освещены результаты научных исследований по патологоанатомическому и гистологическому изучению подопытных кро-ликов, зараженных атипичными микобактериями

Аннотация

В статье освещены результаты научных исследований по патологоанатомическому и гистологическому изучению подопытных кро-ликов, зараженных атипичными микобактериями. Установлено, что послед-ние способны вызывать довольно глубокие патологические процессы в их организме. Эти процессы характеризуются, помимо общих гемодинамичес-ких расстройств, развитием некротических очагов различных размеров в печени. Ключевые слова: атипичные микобактерии, кролики, патвскрытие, морфология, гистоисследование, гистосрезы, внутренние органы. Аннотация: Мақолада туберкулёзнинг нотипик микобактериялари юқтирилган қуёнлар организмининг патологоанатомик ва гистологик текши-ришлар натижалари ёритилган. Тажриба қуёнлари организмида нотипик микобактериялар анча чуқур патологик жараёнлар келтириб чиқариши аниқ-ланган. Мазкур жараёнлар, умумий гемодинамик бузилишлардан ташқари, жигарда турли ўлчамлардаги некроз ўчоқларининг ривожланиши билан ифодаланади. Калит сўзлар: нотипик микобактериялар, қуёнлар, патологоанатомик ёриш, морфология, гистотекшириш, гистокесмалар, ички аъзолар. Relevance of the problem. It is known that livestock breeding is of great importance in improving the agricultural production of the republic, the development of which is impossible without reliable protection of animals from various diseases. However, the increase in the production of livestock products is hampered by various infectious diseases, among which tuberculosis occupies a special place. And this problem is becoming even more acute due to the fact that in recent years the purchase and import of imported highly productive precious cattle has sharply increased. In addition to all this, imported animals are very predisposed and susceptible to atypical mycobacteria, and also react positively in allergy tests for tuberculosis. The disease not only causes significant economic damage, but also has great socio-epidemiological significance. Increasingly, reports are appearing in the scientific literature indicating the identification of a significant number of animals with “nonspecific reactions” during allergy studies. These reactions have been observed in animals infected with so-called atypical mycobacteria. Currently, more than 300 species of atypical mycobacteria are known, the isolation of which has dramatically complicated the problem of eliminating tuberculosis. This is explained by the unreasonable slaughter of highly productive animals and birds that respond positively to the introduction of tuberculin, as well as the imposition of restrictive measures on the farm, household, etc. The import of a large number of cattle to Uzbekistan from neighboring countries and Europe, where atypical mycobacteria are widespread, has further aggravated the task of veterinary specialists. Increasingly, reports are appearing in the scientific literature indicating the identification of a significant number of animals with “nonspecific reactions” during allergy studies. These reactions have been observed in animals infected with so- called atypical mycobacteria. Currently, more than 300 species of atypical mycobacteria are known, the isolation of which has dramatically complicated the problem of eliminating tuberculosis. This is explained by the unreasonable slaughter of highly productive animals and birds that respond positively to the introduction of tuberculin, as well as the imposition of restrictive measures on the 27 28-iyun 2024-yil. Veterinariya sohasidagi dolzarb muammolar yechimi yosh tadqiqotchilar talqinida | TO‘PLAM – 1/24 farm, household, etc. The import of a large number of cattle to Uzbekistan from neighboring countries and Europe, where atypical mycobacteria are widespread, has further aggravated the task of veterinary specialists. Material and research methods. In order to study the pathogenic effect on the morphology of internal organs, an experimental intranasal infection was carried out with reference strains of atypical mycobacteria of rabbits, divided into 3 groups (9 animals each). The first and second groups of rabbits were infected, respectively, with a bacterial mass of M.kansasii and M.intracellulare strains at a dose of 5 mg/kg; the third group served as a control and was not infected. In order to study the dynamics of the development of pathological processes, rabbits were subjected to planned slaughter 2, 4 and 6 months after infection, three animals from each group. At each slaughter, the pathological anatomical picture of the autopsy of all experimental animals was carefully studied. The pathological material obtained from each animal was subjected to appropriate histological processing; after staining with hematoxylin-eosin, all histological sections were examined under a microscope. Research results. During control slaughter, to study the dynamics of the development of pathological processes in the body of experimental animals, the following changes were established: 1 – group. All rabbits killed 2 months after infection showed congesti