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АNALYSIS OF THE ROLE OF FOLATE CYCLE GENES IN THE PATHOGENESIS OF ROSACEA

PATHOGENESIS OF ROSACEA · Azizov B.S. (Tashkent State Dental Institute, Uzbekistan) · Ayupova Sh.T. (Tashkent State Dental Institute, Uzbekistan) · Dyo K.G. (Tashkent State Dental Institute, Uzbekistan) · Khegay T.R. (Institute Of Immunology And Human Genomics Under The Academy Of Sciences Of The Republic Of)

The American Journal of Medical Sciences and Pharmaceutical Research · 05 · 36-39 · 2020

Аннотация

The polymorphism of the genes of the folate cycle was studied. The study identified genes that are presumably involved in the occurrence and development of rosacea, as well as affecting the severity of the disease. Unfavorable variants of the folate metabolism genes: MTHFR: 1298 A>C rs1801131, MTHFR: 677C>T rs1801133. An increase in the level of homocysteine in the blood of patients with rosacea turned out to be significant. The identified loci provide specificity of inflammatory mechanisms in rosacea, and identify potential pathways for therapeutic intervention. KEYWORDS Rosacea, SNP, folate cycle genes. Volume 05 Issue 03-2023 16 The American Journal of Medical Sciences and Pharmaceutical Research (ISSN – 2689-1026) VOLUME 05 ISSUE 03 Pages: 16-22 SJIF IMPACT FACTOR (2020: 5. 286) (2021: 5. 64) (2022: 6. 319) (2023: 7. 396) OCLC – 1121105510 Publisher: The USA Journals

Доказательный фрагмент

«The polymorphism of the genes of the folate cycle was studied.»

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The polymorphism of the genes of the folate cycle was studied. Полный текст публикации CiteX не хранит — доступ к первоисточнику открывается по DOI согласно лицензии издателя и выбранному плану.

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Тип
Журнал
Страна
Узбекистан
Ключевые слова
Rosacea, SNP, folate cycle genes, autoimmune thyroiditis, thyroid nodules, tumors., FNAB, cytology, thyroid gland
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