Диагностическое значение натрийуретического пептида при сердечной недостаточности у детей с врожденными пороками сердца

Аннотация

The aim of the study was to study the clinical and diagnostic significance of natriuretic peptide (BNP) in heart failure (HF) in children with congenital heart defects. Methods. The study included 24 children under 3 years of age with HF. All patients had HF secondary to congenital heart disease and clinical data, echocardiographic parameters were collected. A comparative analysis of the data indicating significant changes in BNP with characteristic changes on the echocardiogram characterizing the signs of heart failure in children was carried out. Study results: analysis of NT-proBNP values and type of heart disease associated with HF. In our cohort, median NT-proBNP was highest in patients with cyanotic heart disease (248.0 fmol/ml), followed by patients with dilated cardiomyopathy (193.3 fmol/ml). The lowest median value of NT-proBNP was recorded in patients with acyano- tic heart disease. Conclusion. In patients with HF, BNP and echocardiography can provide diagnostic and prognostic information. The highest BNP values were reported in patients with lower LVEF, but were not statistically significant. The combination of all these data may offer the best tools for optimizing the treatment of heart failure in children.