Возможности клинико-экономического анализа в оптимизации выбора лекарственных препаратов

Аннотация

Комплексный клинико-экономический анализ препаратов обычно включает частотный анализ, АВС и DDD методологии. Клинико- экономический анализ позволяет определить приоритеты среди закупаемых препаратов, ограничивает возможности бесконтрольного применения лекарственных средств, не относящихся к категории 120 жизненной важности. Он также способствует повышению качества медицинской помощи и главной задачей клинико-экономического анализа является оптимизация технологий приобретения и применения лекарственных препаратов. Ключевые слова: клинико-экономический анализ, антибактериальные препараты, лечение бронхолегочных заболеваний у детей. DORILARNI TANLASHNI OPTIMALLASHTIRISHDA KLINIK- IQTISODIY TAHLIL IMKONIYATLARI Nozima Toxirjonovna Mavlyanova Oilaviy shifokorlik №2, klinik farmakologiya kafedrasi assistenti Toshkent pediatriya tibbiyot instituti, O‘zbekiston. Nazifa Valievna Agzamova Oilaviy shifokorlik №2, klinik farmakologiya kafedrasi dotsenti, t.f.n. Toshkent pediatriya tibbiyot instituti, O‘zbekiston. Annotatsiya. Dori vositalarining keng qamrovli klinik va iqtisodiy tahlili odatda chastota tahlili, ABC va DDD metodologiyalarini o‘z ichiga oladi. Klinik va iqtisodiy tahlil sotib olingan dori vositalari orasida ustuvorlikni belgilash imkonini berib, hayotiy ahamiyatga ega bo‘lgan toifaga kirmaydigan dori vositalarini nazoratsiz qo‘llash imkoniyatini cheklaydi. Shuningdek, u tibbiy yordam sifatini oshirishga yordam beradi va klinik va iqtisodiy tahlilning asosiy vazifasi dori vositalarini sotib olish va ulardan foydalanish texnologiyalarini optimallashtirishda keng ishlatiladi. Kalit so‘zlar: klinik ekonomik tahlil, antibakterial dori vositalari, bolalarda nafas yo‘llari kasalliklarni davolash. The purpose of the research is to analyze data on the use of clinical and economic analysis of antibacterial drugs in children with respiratory diseases. Materials and methods: Materials and methods for studying this type of analysis were by studying the literature data, and research data of foreign scientists and determining the prospects for the development of the application of this analysis in the future in domestic clinics using advanced knowledge in practice. Results: Currently, the problems associated with the use of antibacterial drugs in healthcare are considered taking into account the professional, epidemiological, and economic components of the pharmacotherapy section. In their daily practice, doctors of various specialties regularly prescribe antibiotics to their patients, and the need for the rational use of drugs in this group is very relevant to this day. According to world experts, in almost 50% of cases, 121 antibiotics are used unreasonably. Examples of unjustified cases of antibiotic use are the use of antibacterial drugs without indications, including for prophylactic purposes; the appointment of antibiotics without taking into account the sensitivity of the microflora; the appointment of antimicrobial drugs for viral infections and in a number of other cases. The result of the irrational use of antibacterial drugs is antibiotic resistance. In recent years, there has been a significant increase in the resistance of pathogens to antibacterial drugs. The etiological structure of nosocomial infections is determined by the microbial flora of the specialized hospital, and gram-negative rod pathogens are prevalent here. There is also the problem of structural diversity of resistant community-acquired and nosocomial infections. Accordingly, it is very important to have a “susceptibility passport” of hospital strains, according to which the choice of antibiotic should be made at the empirical stage. The presence of clear criteria for the use of medicines, programs for monitoring the effectiveness of treatment, and monitoring side effects contribute to improving the quality and safety of treatment. The cost of antibiotic therapy is 30% of the budget of medical institutions. In many countries around the world, research is underway to optimize the use of antibacterial drugs and reduce their ongoing costs. For example, in the UK, a randomized controlled trial focused on the strategy of using antibacterial drugs for the most common pathology, lower respiratory infections. In the course of a prospective pharmacoeconomic study, the effectiveness of the implementation of the program was evaluated to reduce the consumption of antibacterial drugs and the cost of antibiotic therapy in medical institutions. In response to the observed significant increase in microbial resistance to penicillin and sulfonamides, Canada is developing a national action plan to regulate the use of antibiotics in the country. Some types of clinical and economic analysis, such as ABC, VEN and DDD, are the most popular and have not only a restrictive function, but can also improve the quality of pharmacotherapy. ABC – analysis, as a variant of clinical and economic analysis, was one of the basic technologies in rationalizing the purchase of d