Фармакологическое действие Тринатриевой соли Глицирризиновой кислоты

Аннотация

Trinatrium salt of glycyrrhizic acid (Glycytrinate) with strong anti-ulcerous activity combined with anti-inflam- matory effect was synthesized on the basis of glycyrrhizic acid. According to the parameters of acute toxicity in experiments on white mice and rats with per oral administration Glycytrinate was included to the group of little toxic substances. And according to the assessment of anti-ulcerous activity on the models of rats’ gastric mucous membrane destruction caused by indo metasin, ortophen, and reserpin glycytrinate has an expressed antiulcer effect. The mechanism of glycytrinate’s antiulcer effect is linked with its antioxidant property and suppression of the secretory function of gastric glands. Keywords: extract Radix glycyrrhizae, glycyrrhizic acid, antiulcer activity. The search of new sources of very active medical agent based on local with cymetidine, which was introduced in the dose 400mg/kg. at the raw materials is a topical problem of the modern science. seventh day all animals were fixed on a desk belly up. In 24 hours all It is known that, Radix glycyrrhizae is widely used in various fields animals were decapitated, gastric mucous membrane was examined of national economy. Its basic component is glycyrrhizic acid. The macroscopically and antiulcer effect of the agents was evaluated. We presence of anti-inflammatory activity, low toxicity, and absence of severe studied the impact of glycytrinate on secretory function of stomach and side-effect make the new synthetic derivatives of glycyrrhizic acid acidity of gastric juice on rats. The agent was introduced per orally for a compounds perspective for medicine [6]. week; in 20 minutes after the last administration of the agent the ligature Glycyrrhizic acid (GA) and its derivatives have strong antiulcer, anti- of pylorus was performed under narcosis. After that in 2-3 hours the inflammatory, antiviral, antitumor and other pharmacological activity. The animals were killed with further measurement of the volume of gastric modern antiulcer agents in the modern time do not completely meet the juice and titration with 0.1 H of NaOH solution till appearance of pink requirements of clinical practitioners, as these agents often cause side- color. In blood serum of rats we determined the activity of super oxide effects, and sometimes even severe complications. Some of these agents dismutase (SOD) [4] and catalase [7]. have insufficient therapeutic effect (5). While continuing the search of new The obtained results were processed with the help of R. V. Strelkov biological active derivatives of glycyrrhizic acid we studied its trinatrium s variation statistic method [9]. salt. The results of the research. The performed experiments showed The objective. To study antiulcer activity of glycytrinate on an that, in the control group of rats the average number of ulcers was experimental model of ulcer caused by 24-hour immobilization of animals 5.66±0.54, and the average summary square area of ulcers was equal to and to reveal the mechanism of antiulcer activity. 6.33+0.54 mm2. Under the influence of glycytrinate the average number Materials and methods. ofulcers and average summary square area of ulcers was diminished to Experimental model of ulcer caused by 24-hour immobilization of 2.33±0.18 and 2.0±0.18 (58% and 68%). Under the influence of animals was performed on rats with body mass equal to 160-200g [1]. cymetidine the average number ofulcers and average summary square area Animals were divided to three groups, with 6 rats in every group. diminished to 4.66+036 and 3.33±0.54 (18% and 48%), respectively, in Glycytrinate 100mg/kg was introduced per orally in experimental groups comparison with the control group. every day for a week prior to stress. And in the control group the same It is known that, an important role in the development of gastric and volume of distillated water was given to the rats. The effect of the agent duodenal ulcer is played by hyper secretion of hydrochloric acid, was compared 103 Section?. Medical science decrease of protective functions of gastric and duodenal mucous We performed clinical testing of glycytrinate on patients with gastric membrane, and its blood supply. and duodenal ulcers in the gastroenterology unit of Tashkent Medical For the detection of the mechanism of antiulcer effect we studied the Academy. influence ofglycytrinate on secretory function of stomach and acidity of It was revealed that glycytrinate has antiulcer and anti-inflammatory gastric juice on rats. Results of the experiment showed that, in the control effect. It is sufficiently effective and has no side-effects. Its efficiency and group of rats the volume of gastric juice was 2.05 ml, pH = 1.33, total tolerance is similar to the agent for comparison De-nol. acidity 0.5 ml, titrated unit was 100 TU. Under the influence of the agent Earlier we determined that, trinatrium salt of glycyrrhizic acid — the volume of gastric juice decreased to 39%,