РОЛЬ ПОЛИМОРФИЗМА ГЕНОВ ФАКТОРА РОСТА ЭНДОТЕЛИЯ СОСУДОВ (VEGF), ГИПОКСИИ ИНДУЦИРОВАННОГО ФАКТОРА-1Α (HIF-1α) И ИНТЕРЛЕЙКИНА 17А (IL-17A) В ПОВЕДЕНИИ АГРЕССИВНЫХ АДЕНОМ ГИПОФИЗА

Аннотация

Pituitary adenomas are considered benign, however, in 20-50% of cases they have an aggressive course. The main criteria for aggressiveness arc frequent recurrences after surgical adenomectomy, resistance to traditional therapy, and massive invasion into nearby structures. The aim of the study was to study the molecular genetic features of invasive aggressive pituitary adenomas (APA). Gene polymorphism of VEGFA, HIF-la, and IL-I7A have been studied in 81 patients (main group) with invasive and non-invasivc pituitary adenomas (main group) and 83 healthy (control group). As a result of the study, it was found that the frequency of occurrence of the studied polymorphisms is more often observed in invasive adenomas and the detection of genotypes varies depending on the course of APA.