ЗАЩИТНАЯ СИСТЕМА СЛИЗИСТОЙ ОБОЛОЧКИ ПОЛОСТИ РТА ПРИ ХРОНИЧЕСКОМ РЕЦИДИВИРУЮЩЕМ АФТОЗНОМ СТОМАТИТЕ НА ФОНЕ ХРОНИЧЕСКОГО ХОЛЕЦИСТИТА

Аннотация

Clinical examination of patients began with clarifying complaints and collecting anamnesis: duration of the disease, provoking factors, treatment, frequency of exacerbations, duration of remissions. The oral mucosa (OOM) was assessed by the presence of lesion elements, their number, localization, the severity of inflammation, the state of the edges of the elements and their sizes. We have studied the quantitative and qualitative composition of microorganisms taken from the oral fluid, then the Petri dishes were placed in a thermostat for 24-48 hours at a temperature of 370C. After incubation, the grown Ig colonies CFU / cm2 were counted, the morphology, cultural, tinctorial and biochemical properties of the grown colonies were studied, thereby establishing the type of microbe. 265 Introduction. One of the important problems of modern dentistry is the study of the pathogenesis of the development of chronic inflammatory processes of the oral mucosa (OOM), especially against the background of concomitant chronic diseases [1,2,3,7,11]. One of these chronic inflammatory processes of OOM is chronic recurrent aphthous stomatitis (RAS), manifested by round or oval aphthates and is characterized by a prolonged course, frequent relapses, combined with somatic diseases, including the gastrointestinal tract. The age of patients is often from 20 to 40 years, in the presence of somatic pathology ranges from 45-60 years. In the structure of general somatic pathology of patients with RAS, 45.9% had chronic cholecystitis [6,8,9,13]. An important role in the pathogenesis of chronic recurrent aphthous stomatitis is played by the state of myсrobiocenosis of the oral mucosa. A decrease in the parameters of cellular and humoral immunity contributes to the excessive growth of microbes, both resident and pathogenic, Candida fungi by 1.5 times in RAS patients with pathology of the hepatobiliary system [4,5,12], of the urogenital system [10] Key words. hepatobiliary system, microbes, somatic diseases, pathogenesis.