OPTIMIZATION OF THE TECHNOLOGY OF “PHOSFARGININE SUCCINATE” INFUSION SOLUTION

Аннотация

In recent years, much attention has been paid to providing the population with domestically produced pharmaceuticals, the production of new import-substituting drugs that are affordable from an economic point of view, important tasks have been identified for “the development of the pharmaceutical industry, as well as improving the provision of the population and medical institutions with cheap, high-quality drugs”. In this regard, the search for new drugs, their introduction into the pharmaceutical industry is being carried out. One of these drugs is "Phosfarginine succinate" (consisting of D-fructose-1,6-diphosphate trisodium salt, L-arginine hydrochloride, succinic acid) infusion solution - a drug that stimulates and regulates the metabolic process. The infusion solution technology was developed on the basis of Temur Med Farm LLC (Republic of Uzbekistan). In order to select a scientifically based composition, develop and optimize the technological process, the method of mathematical planning of the experiment was used - Latin plans. The application of the method of mathematical planning of the experiment made it possible to select the optimal composition and technology of the infusion solution “Phosfarginine succinate”. Volume 04 Issue 11-2022 9 The American Journal of Applied sciences (ISSN – 2689-0992) VOLUME 04 ISSUE 11 Pages: 09-23 SJIF IMPACT FACTOR (2020: 5. 276) (2021: 5. 634) (2022: 6. 176) OCLC – 1121105553 METADATA IF – 7.987 Publisher: The USA Journals KEYWORDS cardiovascular diseases, Phosfarginine succinate, metabolic agent, antihypoxic agent, solution for infusion, composition, D-fructose-1,6-diphosphate trisodium salt, L-arginine hydrochloride, succinic acid, sodium metabisulfite, stabilizer, water for injections, technology, method of mathematical planning of experiment, optimization of composition and technology.