ПОДХОДЫ К МАТЕМАТИЧЕСКОМУ МОДЕЛИРОВАНИЮ ВЗАИМОДЕЙСТВИЙ МАТЕРИНСКОГО И ПЛОДОВОГО КРОВОТОКА

Аннотация

Strategies of multiscale computational modeling, extending from the cellular to the organ level, are the primary tools for studying the dynamic interaction of factors involved in the development of placental dysfunction. Recent years have been marked by significant evolutionary achievements in understanding the physiology and pathophysiology of pregnancy using computational methods for assessing the vascular system not only of the uterus and placenta, but also of the mother and fetus as a whole. So. new approaches in the field of in vivo and ex vivo imaging have given scientists access to the creation of new multiscale models of the uterus and placenta. The multiscale of the models provides a new clinically significant understanding of the pathology of pregnancy and defines the facets on which various scientific disciplines, from cell biology to in vivo imaging, can be combined using computational approaches.