РОЛЬ ГЕНОВ-МЕДИАТОРОВ ИММУННОГО ВОСПАЛЕНИЯ В ДЕСТРУКТИВНО-ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЯХ ГАСТРОДУОДЕНАЛЬНОЙ ОБЛАСТИ У ДЕТЕЙ

Аннотация

A significant contribution to the development of gastroduodenal pathology is made by a violation of the functional activity of the immune system, implemented by T- and B-lymphocytes, in particular, cytokines. This is determined by the pleiotropy of cytokine effects and consists in the regulation of proliferation, differentiation and modulation of apoptotic cell death. The cytokine system includes about 200 individual polypeptide substances, among which are interleukins (IL) 1-37; interferons (INF) a, p and y; tumor necrosis factors (TNF) a and P; colony stimulating factors (CSF); growth factors; chemokines and some others. At the same time, two groups of cytokines are distinguished: anti-inflammatory (IL-l, IL-6, IL-8, IL-12, TNF-a, INF-y), and anti-inflammatory (IL-4, IL-10, IL-13, TGF-P) [5,11,48].