Experience with the use of bacterial lysates in modern medicine

Аннотация

The persistence and recurrent nature of such inflammatory lesions requires not only the usual hygienic measures for the care of the oral cavity and teeth, but also appropriate justified therapy aimed at stimulating the protective forces of the oral mucosa. Relevance of the topic.Macrophages, through the release of cytokines, play a major role in the protective mechanism, causing an increase in the level of T– lymphocytes. The occurrence of non–specific infectious and inflammatory diseases of the pharynx and upper respiratory tract occurs due to an imbalance of local and systemic immunity. The leading role in local immunity is played by cytokines acting on biochemical messengers that regulate the stimulation and inhibition of inflammatory reactions that initiate an immune response. Cytokines are produced by lymphocytes and macrophages embedded in the epithelium of the mucous membrane, the source of cytokines in saliva is serum transudate and salivary glands. Cytokines are also produced by the epithelial cells of the mucous membrane themselves when they come into contact with a microbe. It is important to note that the content of cytokines in saliva does not correlate with their level in the blood, which indicates the autonomy of local immunity. Viral infection can serve as an initiating factor for the attachment of a bacterial 95