Efficacy of treatment of acute herpetic stomatitis. Clinical and immunological parameters of oral cavity in children

Аннотация

Currently, one of the most frequent diseases in children is a herpetic infection, which is explained not only by the prevalence of herpes simplex virus (HSV), but also by the peculiarities of the development of the immune system in a developing child's body. Questions of the general status of herpetic stomatitis in children is important. The purpose of the study was to study the immunological parameters of the oral cavity in children with acute herpetic stomatitis in the dynamics before and after treatment with Kyzyl May. In 62 children with acute herpetic stomatitis who applied to the department of pediatric therapeutic dentistry at TSDI, clinical and immunological studies were conducted. Based on the obtained clinical and immunological data, the high efficacy of Kyzyl May is effective in the treatment of acute herpetic stomatitis. Keywords AHS, Immunology, Lysozyme, Secretory immunoglobulin A, Phagocytic activity of neutrophils A third of the world's population is affected by a herpetic 2. Materials and Methods infection, over half of these patients suffer several attacks of infection over the course of a year, often with manifestations We examined 62 children from 8 months to 3 years with in the oral cavity. It has been established that the infection of acute herpetic stomatitis of moderate severity, who applied children with the herpes simplex virus aged from 6 months to to the department Pediatric Therapeutic Dentistry, Tashkent 5 years is 60%, and by the age of 15 it is already 90% [1,2]. State Dental Institute. Every year, the incidence of children with acute (primary) All children were divided into 2 groups: herpetic stomatitis increases. 1 st group: 30 - children with acute herpetic stomatitis of Acute herpetic stomatitis in children is an infectious viral moderate severity with 0.25% oksolin ointment against the disease caused by primary contact with the herpes simplex background of general treatment. virus, characterized by inflammation of the oral mucosa with 2 nd group: 32 - children with acute herpetic stomatitis of the manifestation of vesicular rash, fever and decreased moderate severity who, against the background of general immunity [3,4]. treatment, used the drug "Kyzyl May" (polyphytic oil). The structure of the oral mucosa in children in early Polyphitic oil "Kyzyl May" is an oily extract of medicinal childhood and the activity of local tissue immunity are of plants, which has antiviral, anti-inflammatory, pain-relieving great importance in the development of herpes infection. and anti-bacterial action. AHS proceeds with hyperemia, edema on the mucous membrane of the oral cavity appear erosion and ulcers, 1. Objective which are covered with white fur. Lesions are from 2-3 to 7-8 mm. Favorite localization of aft on the mucous tongue, lips To study the immunological studies of the oral cavity in and transitional folds. The mucous membranes that are free children with acute herpetic stomatitis to identify indicators from erosion are edematous and hyperemic, the tongue is of local oral immunity before and after treatment. coated with a white-gray bloom, a putrid odor from the mouth, an increase in salivation is noted. Submandibular, * Corresponding author: mental and cervical lymph nodes are enlarged. imahsumova@inbox.ru (Iroda Makhsumova) The complex treatment included general and local Published online at http://journal.sapub.org/ajmms Copyright © 2019 The Author(s). Published by Scientific & Academic Publishing treatment. General treatment used the drug "Acyclovir" This work is licensed under the Creative Commons Attribution International tablets in an age dosage. In the 1st group: local treatment was License (CC BY). http://creativecommons.org/licenses/by/4.0/ 394 Iroda Makhsumova et al.: Efficacy of Treatment of Acute Herpetic Stomatitis. Clinical and Immunological Parameters of Oral Cavity in Children started with antiseptic treatment of the oral cavity with root, which has analgesic properties. On the 3rd day after Furacilin solution 1: 5000 and application of OXOLIN treatment, epithelialization began, the gingival margin 0.25% ointment. became pink, the amount of saliva released decreased, the 2nd group: antiseptic treatment of the oral cavity with duration of treatment was shorter by 2 days. It should be Furacillin 1: 5000 and application with Kyzyl May. noted that there were no allergic reactions to the drug. Table 1. Immunological indicators during the height of the disease and after treatment 3. Research Results Before After treatment Immunological studies were performed in all patients: Immunological Norm treatment 1st group 2nd group indicators quantitative determination of local oral protection factors N=62 N=30 N=32 such as the level of secretory immunoglobulin A, phagocytic Secretory activity of neutrophils and the level of lysozyme in the oral immunoglobulin 2,0 1,45±0,15 1,65±0,1 1,90±0,1 fluid. To determine the phagocytic activity of neutrophils in A, g\l the oral fluid,