Discrepant results in plasma, but not serum in the Beckman Coulter DxI Access HYPERsensitive hTSH 3rd generation assay affect the management of differentiated thyroid cancer and hyperthyroid patients

Аннотация

Thyroid-stimulating hormone (TSH) concentrations are reduced in hyperthyroidism, as a normal physiological response during pregnancy, and in hypothyroid patients being treated with high doses of synthetic thyroid hormone like levothyroxine (LT4). About 1% of the general population suffers from hyperthyroidism [1]. At initial presentation, TSH concentrations may be subnormal in patients with subclinical hyperthyroidism and undetectable ( < 0.01 mU/L) in patients with overt disease. The clinical manifestations of untreated hyperthyroidism and the inappropriately high thyroid hormone actions, or thyrotoxicosis, include weight loss, osteoporosis, cardiovascular complications and even death.