Safety and efficacy of triple therapy with peginterferon, ribavirin and boceprevir within an early access programme in Spanish patients with hepatitis C genotype 1 with severe fibrosis: SVRw12 analysis

Аннотация

The natural course of an untreated or unsuccessfully treated chronic hepatitis C virus (HCV) infection leads to the development of liver fibrosis, which may progress to cirrhosis, severe liver failure, hepatocellular carcinoma or death . The rate of progression to cirrhosis is variable, and is influenced by several factors, such as alcohol consumption, age at the time of HCV infection, degree of liver fibrosis, HCV genotype, coinfection with human immunodeficiency virus and hepatitis B virus and other comorbid conditions. Liver disease because of HCV infection and its complications are the most common indication for liver transplantation .