ChromContact: A web tool for analyzing spatial contact of chromosomes from Hi-C data

Аннотация

Hi-C can detect genome-wide three-dimensional (3D) chromatin interactions by cross-linking spatially proximal genomic fragments followed by high-throughput pairedend DNA sequencing [1]. Hi-C was successfully applied to unveil genome-wide long-range interactions [2] such as the relationship between distant enhancers and promoters. Recently reported Hi-C experiments identified a huge amount of spatial contact between genomic fragments, which contain known distant enhancers and their target genes, at 5–10-kb resolution [3]. More recent experiments achieved an even higher resolution [4].