IMMUNOSUPPRESSANTS IN MODERN PHARMACOLOGY: MECHANISMS OF ACTION AND CLINICAL APPLICATION

Аннотация

The immune system is a complex network of cells and mediators designed to protect the body from pathogens. However, in some cases (organ transplantation, autoimmune and allergic diseases) this protective reaction becomes excessive or directed against one's own tissues, which requires pharmacological correction. Immunosuppressants are a heterogeneous group of drugs that specifically inhibit the immune response. Their introduction revolutionized transplantology and significantly improved the prognosis for many autoimmune pathologies. However, their use is associated with serious side effects, primarily with an increased risk of infections and cancer, which dictates the need to search for new, more selective targets and drugs.