STUDY OF THE COMBINED ACTIVITY OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE AND TETRAMETHYLENEDIAMINETETRAMINE AGAINST CLINICAL ISOLATES

Аннотация

The widespread availability and use of antibacterial and antiseptic agents have led to the emergence of antimicrobial resistance among many strains of pathogenic and conditionally pathogenic microorganisms. Antibiotic resistance poses a particular challenge in the treatment of nosocomial infections in hospital settings, especially in intensive care units (ICUs). Addressing the pharmacotherapy of nosocomial infections in ICUs remains one of the most pressing issues in modern medicine. To tackle this problem, novel antimicrobial agents as well as their combined activity are being investigated. Synergistic interactions between antimicrobials can facilitate therapy and enhance efficacy at lower doses, thereby reducing adverse and toxic effects on the human body