POLYPHENOLS AS POTENTIAL INHIBITORS OF SARS-COV-2 CORONAVIRUS: AN IN SILICO STUDY

Аннотация

Currently, the search for antiviral substances is carried out in two ways: 1. Repurposing existing and screening newly synthesized compounds. 2. Targeted search for natural biologically active substances, in most cases, using computer modeling. The main disadvantage of all currently used drugs is their fairly high toxicity and, as a consequence, the presence of side effects. In the development of new drugs for the treatment of COVID-19, polyphenolic compounds are of particular interest. Studies conducted by scientists from different countries have shown that plant polyphenols are promising polyfunctional compounds with great potential as active ingredients for the creation of new pharmaceutical substances with antiviral activity