COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF EMHPS AND ITS METABOLITE EMSP ON RESPIRATORY PARAMETERS, MOTOR ACTIVITY AND GENE EXPRESSION OF MITOCHONDRIAL COMPLEXES IN MICE UNDER CONDITIONS OF INTERMITTENT HYPOXIA

Аннотация

Intermittent hypoxia (IH) is a pathological factor that provokes oxidative stress, which can initiate a cascade of pathological conditions, mitochondrial dysfunction, inflammation, endothelial dysfunction and metabolic disorders. In this regard, the study of active antioxidants is relevant. In this work, we studied the antihypoxic properties of the metabolite of ethylmethylhydroxypyridine succinate (EMHPS) - ethylmethylsulfapyridine (EMSP) on the IH model in mice. In previous studies, EMSP exhibited antihypoxic and antioxidant properties [1-3].