INHIBITORY EFFECT OF LUTEOLIN ON FSH-INDUCED 17β -ESTRADIOL BIOSYNTHESIS

Аннотация

In women of reproductive age, estrogen is a C18 steroid with diverse physiological roles, primarily produced by the granulosa cells of the ovaries through endocrine signaling. Its functions include promoting the development of secondary sexual traits, controlling gonadotropin release to trigger ovulation, preparing tissues for progesterone activity, preserving bone density, regulating lipoprotein metabolism, preventing urogenital atrophy, modulating insulin sensitivity, and supporting cognitive health. In healthy premenopausal women, 17β-estradiol (E2) is the predominant circulating estrogen, synthesized in the ovaries. This synthesis occurs through the aromatization of androstenedione into estrone (E1), which is subsequently converted into 17β-estradiol. During normal menstrual cycles, 17β-estradiol functions as a systemic hormone, exerting regulatory actions on distant target tissues.