SYNTHESIS OF SUPERCHARGED CHITOSAN DERIVATIVES

Аннотация

Modern polymer chemistry is actively evolving toward the development of functionalized biopolymers with tailored physicochemical and biomedical properties. Chitosan, a derivative of chitin, is a polymer containing reactive amino groups, which makes it a promising raw material for the design of novel biologically active macromolecular systems. One of the key requirements for chitosan derivatives is their solubility under neutral or mildly alkaline conditions. However, the limited solubility of native chitosan significantly restricts its practical applications. Therefore, the development of highly charged chitosan derivatives remains a relevant and promising research direction. In this context, the introduction of cationic groups into the chitosan backbone can enhance not only its solubility at neutral or slightly alkaline pH values but also its inherent biological activity.