SYNTHESIS OF POLYMERIC NITROGEN DONATIONS BASED ON INULIN DERIVATIVES

Аннотация

Nitric oxide (NO) donors are widely used in the treatment of cardiovascular diseases, pulmonary hypertension, and are also actively studied in the treatment of neurodegenerative pathologies. Such drugs as Nitroglycerin, Molsidomine and Nicorandil are capable of releasing nitric oxide. In the context of the growing number of chronic diseases and an aging population, there is a growing need for effective and safe means regulating the bioavailability of NO. In addition, the improvement of synthesis methods makes it possible to obtain nitrogen donors with a given structure that ensures controlled release of NO under physiological conditions of the body. For these reasons, the development of new methods for the synthesis of nitrogen donors with controlled release and high biocompatibility is becoming a particularly interesting task.