Clinical manifestations and hormonal disorders in children with primary hyperparathyreoidism complicated urolithiasis

Аннотация

Hyperparathyroidism (HPT) in children is manifested by nephrolithiasis, nephrocalcinosis, and in 80-100% of cases, recurrence of kidney stones is observed. The aim of this work was to study the effects of calcium and calcium regulatory hormones on the clinical course of urolithiasis of hyperparathyroid genesis in children. From 2010 to 2019, 52 children with urolithiasis were diagnosed with primary hyperparathyroidism based on clinical and biochemical studies. Clinical symptoms and syndromes of the disease depended on the level of calcium and calcium-regulating hormones, and differed from the course of the disease in children with urolithiasis (control). In children of the second age group, the disease was difficult, with pronounced changes in organs and systems, exacerbating the course of the underlying disease. The developed renal failure and sclerotic changes in the renal tissue contributed to the disappearance of the difference in laboratory parameters between age groups.