THE ROLE OF IMMUNE IMBALANCE IN THE PATHOGENESIS OF OSTEOFOLLICULITIS IN DERMATOVENEREOLOGY AND THE POSSIBILITIES OF IMMUNOTHERAPY IN ITS CORRECTION

Аннотация

Relevance: Osteofolliculitis, one of the most common forms of staphyloderma, often becomes chronically relapsing, significantly reducing the quality of life of patients and posing a complex therapeutic problem. Standard antimicrobial therapy is often insufficiently effective in achieving stable remission, indicating theimportant roleof disorders in thehost immunesystem. The purpose of the study: to study the features of immune imbalance in patients with chronic recurrent osteofolliculitis and to evaluate the clinical and immunological effectiveness of including immunocorrective therapy in complex treatment. Methods: The study involved 60 patients with chronic osteofolliculitis, divided into two groups: the main group (n=30) receiving standard therapy in combination with an immunomodulator, and the control group (n=30) receiving only standard therapy. Clinical dynamics, quality of life (DLQI index) and immunological parameters (T-lymphocyte subpopulations, serum immunoglobulin levels, neutrophil phagocytic activity) were assessed. Results: Patients with osteofolliculitis had significant disturbances in the cellular and humoral immunity before treatment. The use of combination therapy in the main group led to more rapid regression of rashes, improved quality of life, normalization of immunological parameters and a significant decrease in the relapse rate during the 6-month observation period compared to the control group. Conclusions: Immune imbalance is a key pathogenetic factor in the chronic course of osteofolliculitis. Inclusion of immunotherapy in complex treatment is a pathogenetically substantiated approach that allows increasing theeffectiveness oftherapy and achieving long-term remission. Keywords: osteofolliculitis, pathogenesis, immune imbalance, secondary immunodeficiency, T-lymphocytes, immunoglobulins, immunotherapy, combination treatment, dermatovenereology. РОЛЬИММУННОГО ДИСБАЛАНСАВПАТОГЕНЕЗЕОСТЕОФОЛЛИКУЛИТА В ДЕРМАТОВЕНЕРОЛОГИИИ ВОЗМОЖНОСТИ ИММУНОТЕРАПИИ В ЕГО КОРРЕКЦИИ