DIFFERENCES IN IMMUNOHISTOCHEMICAL MARKER EXPRESSION ACROSS AGE GROUPS IN POST-TRAUMATIC NASAL POLYPOSIS

Аннотация

Nasal polyposis (NP) is a chronic inflammatory disease of the sinonasal mucosa, often associated with structural abnormalities such as post-traumatic nasal septum deviation. Persistent inflammation following trauma induces repeated immune activation, leading to polyp formation and remodeling of the mucosal architecture. The immune response, however, is strongly influenced by patient age, resulting in distinct patterns of immunohistochemical marker expression. Understanding these differences is crucial for clarifying disease pathogenesis and developing age-specific therapeutic approaches.