Prospects for the Use of Carboxytherapy in Comprehensive Care for Problematic Skin

Аннотация

PUBLISHED 23 August 2025 This article presents a comprehensive analysis of the VOLUME Vol.07 Issue 08 2025 prospects for applying non-injection carboxytherapy CITATION within integrated care programs for problematic skin, Pieieva Irina. (2025). Prospects for the Use of Carboxytherapy in Comprehensive Care for Problematic Skin. The American Journal of taking into account contemporary demands for efficacy, Medical Sciences and Pharmaceutical Research, 7(8), 44–50. safety, and physiological compatibility of interventions. https://doi.org/10.37547/tajmspr/Volume07Issue08-07 The study is grounded in an interdisciplinary framework combining clinical dermatology, cosmetology, skin COPYRIGHT © 2025 Original content from this work may be used under the terms physiology, and evidence-based medicine. Special of the creative commons attributes 4.0 License. attention is paid to secondary analysis of scientific literature describing the effects of transdermal and topical CO₂ application on vascular, pigmentary, and structural skin parameters in patients with acne, post- acne, striae, hyperpigmentation, and early cellulite. Both visual-instrumental and clinical outcomes are examined—including skin hydration, elasticity, microcirculation, lymphatic drainage, and patient satisfaction. Findings indicate that noninvasive CO₂ modalities—such as gel formulations, masks, and device-assisted transdermal delivery—produce significant clinical improvements, particularly in the periorbital area and regions with compromised turgor, while maintaining a high safety profile and requiring no recovery time. A comparative review with alternative approaches (PRP, fractional CO₂ laser, IPL) highlights the superior tolerability and multifunctional benefits of noninvasive carboxytherapy, especially for patients with sensitive or thin skin. Limitations of the current evidence base are also identified: variability in treatment protocols, short observation periods, and the lack of standardized efficacy scales. The necessity for methodological standardization and an increase in randomized controlled trials is substantiated. This article The American Journal of Medical Sciences and Pharmaceutical Research 44 https://www.theamericanjournals.com/index.php/tajmspr The American Journal of Medical Sciences and Pharmaceutical Research will be of value to specialists in aesthetic medicine, problematic and sensitive skin; to substantiate its clinical dermatologists, skin physiology researchers, and efficacy within comprehensive dermocosmetic developers of personalized, multitargeted skincare restoration protocols; and to identify directions for regimens. future research in non-invasive CO₂–based methodologies. Keywords: non-injection carboxytherapy, problematic skin, transdermal delivery, CO₂ gels, periorbital area, Materials and Methods striae, hyperpigmentation, microcirculation, The methodological framework of this study is situated physiological skincare, aesthetic dermatology. at the crossroads of clinical dermatology, aesthetic Introduction medicine, and physiological cosmetology, reflecting the interdisciplinary nature of analyzing non-injection Contemporary cosmetology—both within countries carboxytherapy’s efficacy in correcting aesthetic skin boasting established dermatological care systems and in imperfections. The principal analytical tool is a private aesthetic medicine settings across the post- qualitative content analysis of both scientific and Soviet region—is undergoing a significant shift driven by applied literature addressing the mechanisms of a reappraisal of the balance between efficacy and transdermal CO₂ action, its effects on skin condition, and invasiveness of treatments. Increasing prevalence of its incorporation into non-invasive skincare regimens. skin sensitivity, heightened susceptibility to inflammatory reactions, and chronic dermatoses across Our review draws on sources encompassing clinical all age groups have prompted a move toward overviews and applied studies of skin hydration, physiologically gentle techniques. In this context, elasticity, vascular and pigmentary disorders, textural interest is growing in non-injection carboxytherapy: a changes, and cellulite. Particular emphasis is placed on modality relying on localized application of carbon the work of Kołodziejczak [1], which reports changes in dioxide to enhance microcirculation, tissue oxygenation, hydration and viscoelasticity of the lower‐eyelid skin and regenerative processes without compromising skin following CO₂ monotherapy and combined CO₂–acid integrity. treatments, and on Kołodziejczak and Rotsztejn [2], who demonstrate carboxytherapy’s impact on the vascular Particular attention in both research and practice has and pigmentary components of periorbital dark circles. focused on transdermal CO₂ therapies—gel applications, We also consider systematic reviews by Martignago et masks, and device-based methods—that facilitate gas al. [3], Kroumpouzos [4], and Z