MORPHOFUNCTIONAL CHANGES IN THE NEURAL ENVIRONMENT IN SUICIDE

Аннотация

The presented analytical review of literature addresses the state of the study of the morphology of microglia, astrocytes, oligodendrocytes, and the blood-brain barrier in suicide. According to the generalized data, the most characteristic localization of changes in the development of suicidal behavior was determined by the suture nucleus, prefrontal and anterior cingulate cortex. There is evidence of a correlation between the development of suicidal behavior and an increase in inflammatory cytokines in the prefrontal cortex, disruption of the connection between astrocytes and oligodendrocytes in the anterior cingulate cortex, as well as indication of involvement in the process of forming suicidal behavior of the cortex, striatum, preclinium and cuneiform, orbitofrontal cortex.