BIOLOGICAL ACTIVITY OF QUATERNARY AMMONIUM SALTS DERIVED FROM AROMATIC TERTIARY AMINES

Аннотация

Reactions between pyridine and certain esters of monochloroacetic acid were carried out to obtain quaternary ammonium salts. As a result of these reactions, a quaternary ammonium salt of pyridine was synthesized. The optimal reaction conditions were studied, and the yields of the resulting salts were calculated. Although chitosan is known for its high biological activity, its limited solubility in water restricts its range of applications. Therefore, the synthesis of quaternary ammonium salts based on chitosan is considered an important reaction. A novel quaternary ammonium salt of chitosan was synthesized using the quaternary ammonium salt of pyridine. The resulting cationic chitosan derivative exhibited antibacterial properties. The synthesized compounds were analyzed using physicochemical methods, including IR and NMR spectroscopy. The results confirmed theformation ofthequaternary ammonium salt ofchitosan. Keywords: Pyridine, chitosan, esters of monochloroacetic acid, DMF, ethanol, acetone, temperature, IR, NMR.