SYNTHESIS OF QUATERNARY AMMONIUM SALTS BASED ON ETHYLENE CHLOROHYDRIN AND THEIR MODIFICATION WITH CHITOSAN

Аннотация

A quaternary ammonium salt was synthesized based on ethylene chlorohydrin. Alternative reaction conditions were studied to optimize the synthesis process. The resulting quaternary ammonium salt was subsequently reacted with chitosan. Given the inherently high biological activity of chitosan, its conversion into a quaternized, positively charged form was found to further enhance its bioactivity. The synthesized compounds were analyzed using physicochemical methods, including IR and ¹H NMR spectroscopy. The obtained data confirmed thesuccessful formation ofthequaternary ammoniumchitosan derivative. Keywords:Ethylene chlorohydrin, Chitosan, DMF, Ethanol, Choline, Trabectedin, Solifenacin, Noscapine, Quinapril, IR spectrum, ¹HNMR spectrum