The role of angiogenic growth factors in the pathogenesis of preterm labor in pregnant women on the background of undifferentiated connective tissue dysplasia with mitral valve prolapse

Аннотация

The soluble forms of VEGF, sVEGF-R1(sFlt-1), sVEGF-R2 (sKDR), MMP-2, MMP-9, TIMP-1 and TIMP-2 were determined in their sera by enzyme immunoassay, by using the standard test systems (Bender MedSystems GmbH (Austria) and R&D Systems (USA)). The findings were used to calculate the ratios of pro- and antiangiogenic factors. The findings suggest that analysis of ligand/receptor pairs may be used to characterize the processes of angiogenesis in premature birth. Moreover, the VEGF/VEGF-R1, VEGF/VEGF-R2, and MMP-9/TIMP-1 ratios are of the greatest informative value. The nature of intragroup changes in the VEGF/VEGF-R1 and VEGF/VEGF-R2 ratios in the examined pregnancy periods proposes that there is a unified mechanism that regulates relationships between VEGF and its receptors VEGF-R1 and VEGF-R2. The PLGF/VEGF-R1 and MMP-2/TIMP-2 ratios are of low informative value.