ANTIBODY TITERS TO BACTERIAL ANTIGENS IN COLON DYSBIOSIS

Аннотация

The levels of antibodies to enterobacteria of intestinal microflora in dysbiosis of the large intestine and in practically healthy individuals were determined. Cellular sensitization to antigens of intestinal microflora and its significance in extraintestinal manifestations of dysbiosis (morbidity, susceptibilityto infections, allergies) were determined. The risk groups for secondary immunodeficiency were determined by the magnitude of antibody titers to intestinal microflora antigens (antibodies to intestinal microflora as a marker ofimmunodeficiency). The place of the antimicrobial immunity system in the development of immunopathology in dysbiosis ofthelarge intestinewas established. The presence of antibodies against UPE enterotoxin was revealed in all examined children. A relationship was established between an increase in the age of children with the detection of antibodies, as well as an increase in the intensity of formation of antienterotoxic antibodies in thebloodserum ofchildren with dysbiosis ofthe largeintestine. A relationship was established between dysbiosis of the large intestine and the state of the antimicrobial immuneresponseofthe bodyofchildren. Keywords: Intestinal Dysbiosis, Intestinal Microflora, IFA, diarrhea, coprofiltrate, protease.