LIVING DONOR AND DECEASED DONOR LIVER TRANSPLANTATION: CLINICAL OUTCOMES AND FUTURE DIRECTIONS

Аннотация

Liver transplantation is the standard of care for patients with end-stage liver disease and acute hepatic failure. The increasing gap between organ demand and availability has accelerated the development of living donor liver transplantation (LDLT) as a complementary approach to deceased donor liver transplantation (DDLT). This study analyzes 250 patients who underwent liver transplantation between 2016and 2023, comparing outcomes between LDLT and DDLT, evaluating postoperative complications, graft survival, and quality of life. The study also examines recent innovations, including machine perfusion and immunosuppressive strategies. Results demonstrated comparable one- and five-year survival rates for both groups, with LDLT reducing waiting list mortality by 35%. Advances in perioperative care and Enhanced Recovery After Surgery (ERAS) protocols significantly improved postoperative recovery. These findings highlight the vital role of both living and deceased donor programs in addressing organ shortages and optimizing outcomes in livertransplantation. Keywords: Liver transplantation, Living donor liver transplant, Deceased donor, End-stage liver disease, Immunosuppression, Graft survival, ERAS.