STUDY OF THE STATE OF CENTRAL VIEW AND THE VISUAL FIELD IN PATIENTS WITH HEMOLYTIC ANEMIA BASED ON THE USE OF STATICALLY AUTOMATED PERIMETRY

Аннотация

In this study, changes in central vision and visual field were studied using static automated perimetry in 19 patients with hemolytic anemia. The main goal of the study is to determine the influence of anemia on the visual system by assessing the state of ocular microcirculation and nerve fibers. The obtained results showed significant narrowing of the visual field and a decrease in sensitivity, which justifies the need for advanced diagnostics andmonitoring. Keywords:hemolytic anemia, visualfield, staticperimetry, centralvision, visual function. ИЗУЧЕНИЕСОСТОЯНИЯЦЕНТРАЛЬНОГОЗРЕНИЯ И ЗРИТЕЛЬНОГО ПОЛЯУ БОЛЬНЫХГЕМОЛИТИЧЕСКОЙ АНЕМИЕЙНАОСНОВЕ ИСПОЛЬЗОВАНИЯСТАТИЧЕСКОЙАВТОМАТИЗИРОВАННОЙ ПЕРИМЕТРИИ. Аннотация: В данном исследовании были изучены изменения центрального зрения и поля зрения с помощью статической автоматизированной периметрии у 19 пациентов с гемолитической анемией. Основной целью исследования является определение влияния анемии на зрительную систему путем оценки состояния микроциркуляции глаз и нервных волокон. Полученные результаты показали значительные сужения полей зрения и снижение чувствительности, что обосновывает необходимость более совершеннойдиагностикии мониторинга. Ключевые слова: гемолитическая анемия, поле зрения, статическая периметрия, центральноезрение,зрительная функция. GEMOLITIKANEMIYA BILANOG‘RIGAN BEMORLARDASTATIK AVTOMATLASHTIRILGAN PERIMETRIYADAN FOYDALANISH ASOSIDA MARKAZIY KO‘RISHVA KO‘RISHMAYDONINING HOLATINIO‘RGANISH Annotatsiya Ushbu tadqiqotda gemolitik anemiya bilan og‘rigan 19 nafar bemorda statik avtomatlashtirilgan perimetriya yordamida markaziy ko‘rish va ko‘rish maydoni o‘zgarishlari o‘rganildi. Tadqiqotning asosiy maqsadi ko‘z mikrotsirkulyatsiyasi va nerv tolalari holatini baholash orqali vizual tizimga anemiya ta’sirini aniqlashdir. Olingan natijalar ko‘rish maydonida sezilarli torayishlar va sezuvchanlik pasayishini ko‘rsatdi, bu esailg‘ordiagnostika vamonitoringzaruratini asoslaydi. 98,7:ROTCAFTCAPMI.SECNEICSLACIDEM ,5202 , yluJ,5emuloV gro.srehsilbupcimedaca.www Kalit so’zlar gemolitik anemiya, ko‘rish maydoni, statik perimetriya, markaziy ko‘rish, vizual funktsiya. Hemolytic anemia is a pathological condition characterized by the accelerated destruction of erythrocytes, leading to a decrease in their lifespan and a consequent imbalance in the oxygen-transporting capacity of the blood. This condition often results in systemic hemodynamic disturbances and chronic tissue hypoxia, which may adversely affect various organs, including the visual system. The ocular tissues, particularly the retinal neurons and microvascular structures responsible for central visual field integrity, are highly sensitive to hypoxicconditionsand oxidativestress induced byhemolytic processes. In this context, static automated perimetry represents a highly sensitive and objective diagnostic modality used to evaluate functional impairments in the visual field. It provides precise quantification of differential light sensitivity across the retina and is instrumental in detecting both early and subtle changes in visual function, particularly in patients with systemicdisorders that may compromise ocularperfusion andneural conductivity. Study Base: The present study was conducted at the Republican Specialized Scientific and Practical Medical Center of Ophthalmology over the period of 2024–2025. The research facility provided advanced ophthalmic diagnostic equipment and experienced personnel, which enabled high-quality data collection and reliable analysis of visual field parameters in patients withhematological disorders. Study Population: A total of 19 patients diagnosed with hemolytic anemia were enrolled in the study. The cohort included 11 female and 8 male participants. The age of the patients ranged from 18 to 52 years, with a calculated mean age of 34 years (±9.1). All participants were selected based on confirmed clinical and laboratory diagnoses of hemolytic anemia, and none had prior history of primary ophthalmic disorders that could affect perimetric outcomes. Methodology: The evaluation of central visual function and visual field integrity was carried out using static automated perimetry. Specifically, the Humphrey Field Analyzer (HFA) with the 30-2 SITA-Standard protocol was employed. This protocol is widely accepted as a gold-standard method for assessing visual field sensitivity in both clinical and research settings. Prior to the test, all patients were given clear instructions and underwent a brief practice session to ensurecompliance and understanding oftheperimetric procedure. Measured Parameters: Three primary quantitative parameters were obtained and analyzed foreachpatient: 1. Mean Deviation (MD): This value reflects the overall deviation of the patient's visual field sensitivity from age-adjusted normative values. Negative MD values indicate a generalizeddepression in visual sensitivity. 2. Pattern Standard Deviation (PSD): PSD is an indicator of localized irregularitie