EFFECTIVENESS OF RUTAN IN CORRECTING DISORDERS OF LIPID PEROXIDATION IN PREPUBERTAL RATS WITH ACUTE TOXIC HEPATITIS

Аннотация

Considering the increasing incidence of toxic liver damage—the primary organ for xenobiotic detoxification—the insufficient effectiveness of currently used pharmacological treatments necessitates the search for and implementation of new effective drugs for treating hepatobiliary system pathology in prepubertal patients. In this context, the authors studied the effects of Rutan and Karsil on the levels of lipid peroxidation products (Acylhydroperoxides [AcGP], malondialdehyde [MDA]) and the activity of antioxidant enzyme systems (catalase [CAT], superoxide dismutase [SOD]) in the liver during acute hepatitis induced by carbon tetrachloride in one-month-old rats. Results showed that Rutan, similarly to Karsil, reduces elevated levels of AcGP and MDA in the microsomal-cytosolic liverfraction significantly increased by acute toxic hepatitis induced by carbon tetrachloride. Notably, this effect is accompanied by increased activity of antioxidant enzyme systems. It was concluded that Rutan may be used in the treatment of acute liver diseases in the prepubertal period. Keywords: acute toxic hepatitis, rats, prepubertal period, liver, free radical oxidation, antioxidantdefense enzymes. Conflict of interest. The authors declare no actual or potential conflicts of interest related to thepublicationof thisarticle.