The Significance of Risk Factors in The Development of The Combined Form of Bronchial Asthma in Children

Аннотация

The characteristics of bronchial asthma combined with allergic rhinosinusitis have been identified: a more severe course of the disease, bronchial hyperreactivity, and decreased activity of the body's nonspecific defense mechanisms. Risk factors and non-infectious allergens play a significant role in the formation and development of bronchial asthma. Allergic rhinosinusitis determines the severity of the clinical course of bronchial asthma. Keywords: Bronchial asthma, bronchial hyperreactivity, risk factors. increased more than 20-fold (2,3,4). The condition is Introduction: Objective of the study. To investigate the especially prevalent among children living in clinical features and determine the significance of risk environmentally unfavorable regions (1,3,5). Although factors in the development of atopic bronchial asthma various aspects of bronchial asthma have been actively combined with allergic rhinosinusitis (ARS) in children. researched, many questions remain unresolved. In this Methods. A study was conducted involving 100 regard, the issue of combined forms of bronchial children aged 7 to 14 years suffering from atopic asthma with other allergic diseases presents significant bronchial asthma, both with and without ARS. A control scientific and practical interest. For instance, there are group consisted of 30 practically healthy children. contradictory opinions regarding bronchial asthma Clinical-allergological, functional, laboratory, associated with allergic rhinosinusitis (ARS). It is immunological, and statistical research methods were believed that primary pathology of the upper used. respiratory tract plays a significant role in the Results. Specific clinical features of atopic bronchial development and clinical manifestation of bronchial asthma combined with ARS were identified: asthma (1,2,4,5). predominance of cases with more severe clinical The objective of the study was to examine the clinical course, pronounced meteorological sensitivity, characteristics and determine the risk factors in the psychological disturbances, hyperreactivity of development of atopic bronchial asthma associated bronchial receptors to histamine and acetylcholine, with ARS in children. suppression of external respiratory function, impaired METHODS rhinometry indicators, and decreased phagocytic activity of neutrophils. The significance of risk factors The study observed 130 children aged 7–14 years, (predisposing and contributing) for the development of including 60 suffering from atopic bronchial asthma bronchial asthma in children was established. combined with allergic rhinosinusitis (ARS), 40 with atopic bronchial asthma without ARS, and 30 practically Relevance of the problem. The urgency of the healthy children. The diagnoses of the primary and bronchial asthma issue is due to its steady increase in associated conditions were established based on incidence worldwide, often with more severe clinical clinical-allergological, functional, laboratory, and manifestations and a high risk of fatal outcomes (1,2). radiological examinations. Forced expiratory power, Uzbekistan is no exception, where over recent years, sensitivity threshold of the bronchial receptor the incidence of bronchial asthma among children has International Journal of Medical Sciences And Clinical Research 11 https://theusajournals.com/index.php/ijmscr International Journal of Medical Sciences And Clinical Research (ISSN: 2771-2265) apparatus to histamine and acetylcholine, nasal RESULTS AND DISCUSSION respiratory function, eosinophil count in peripheral Analysis of the results showed that atopic bronchial blood and nasal secretions, and the cause of asthma was more common in boys (65.0–71.7%) than sensitization were determined using allergic skin tests. in girls (28.3–35.0%) (Table 1). The set of paraclinical studies included the evaluation In the majority of affected children—38 cases of serum IgE levels, phagocytic activity of neutrophils, (63.3%)—the onset of bronchial asthma began with and the psychological state of the children (1,2,4,6,8). symptoms of allergic rhinitis and sinusitis. In 18 children Statistical analysis was carried out using the Microsoft (30.0%), the disease started with simultaneous Windows application software package. The manifestations of bronchial asthma and ARS significance of differences between the compared symptoms. In only a few children—4 cases (6.7%)—the values was assessed using the Student’s t-test. disease began with bronchial asthma symptoms, and Correlations among the studied parameters were symptoms of allergic inflammation of the nose and its evaluated using the correlation coefficient, with paranasal sinuses appeared some time later. statistical significance set at p ˂ 0.05. Characteristics of Children by Clinical Forms of Disease Manifestation, Gender, and Age Table 1. № Name of 7 – 12 years 13 – 14 years Total the Boys Girls Boys Girls Boys Girls Total Condition 1. Bronchial 13 7 30 10 43 17 60 asth