Сharacteristics of markers of endothelial dysfunction in the blood of women with preterm birth

Аннотация

Recently, vascular and hemodynamic disorders in the mother, which are observed in various somatic diseases, have traditionally been attributed to risk factors for preterm birth. At the heart of violations of hemodynamics and mi- crocirculation, including in the uteroplacental pool, developing with preeclampsia and various somatic pathologies, is a generalized dysfunction of the endothelium. It is extremely important to study the content in the blood of pregnant women with premature birth of indicators of the anticoagulant potential of the blood, in particular, the content of the main anticoagulant, antithrombin III. In preterm birth, its amount was 85.15 ± 5.31 mg/l, which is significantly lower than in women with a physiological course of pregnancy, which indicates the important role of antithrombin III defi- ciency in the development of these severe pregnancy complications.